Chemical Name |
Gidazepam |
CAS Number |
129186-29-4 |
MDL Number |
MFCD00947092 |
Molecular Formula |
C17H15BrN4O2 |
Molecular Weight |
387.23 |
Synonyms |
Gidasepam;Hidazepam; Hydazepam |
Introduction of 129186-29-4 :
Gidazepam is an agonist of GABA receptor channels (GABA RCs). IC50 & Target: GABA receptor[1] In Vitro: Gidazepam demonstrates considerably lower affinities to GABA RCs than phenazepam, 3-hydrozyphenazepam, and Br-nordiazepam. This is manifested in different values of the inhibition constant (Ki) of binding of a specific ligand of benzodiazepine receptors, diazepam. For Gidazepam, the Ki value is 2,200±50 nM[1]. In Vivo: Mice are distributed into 10 groups of five animals each, treated orally with Gidazepam (GDZ, 1 mg/kg); ester 1 (175 mg/kg); ester 2 (20 mg/kg); esters 3 and 4 (200 mg/kg); mixtures of Gidazepam and esters 1-4. All esters of GABA with monoterpenes display antiseizure effects in 3 h after oral administration as evidenced by increasing of inducing clonic-tonic convulsions (DCTC) and tonic extension (DTE) values. Gidazepam (1 mg/kg) is found to protect against seizures with DCTC and DTE values of 250% and 215%, accordingly; whereas co-administration of Gidazepam and esters 5-7 is shown to increase anticonvulsant activity compared with each compound alone[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.