Chemical Name |
Rat CGRP-(8-37) |
CAS Number |
129121-73-9 |
MDL Number |
MFCD00671419 |
Molecular Formula |
C138H224N42O41 |
Molecular Weight |
3127.51 |
Introduction of 129121-73-9 :
Rat CGRP-(8-37) (VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF) is a highly selective CGRP receptor antagonist. IC50 & Target: CGRP receptor[1] In Vitro: CGRP-(8-37) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity but does not activate the receptor[1]. In Vivo: CGRP-(8-37) is effective in alleviating mechanical and thermal allodynia in a dose-dependent manner. The 50 nM dose is most efficacious for both forelimb and hindlimb responses. The period of efficacy is 10 min to onset for a duration of 20 min. Post-drug washout responses are not statistically significant compared to pre-drug responses[1]. Intrathecal administration of 5 nmol or 10 nmol of CGRP-(8-37), but not 1 nmol, induces a significant increase in hindpaw withdrawal latency. Intrathecal administration of CGRP-(8-37) not only reverses the SP-induced decrease in latency to both withdrawal responses but also mediates a significant increase in response latency compared to basal levels[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.