Chemical Name |
RAD51 Inhibitor B02 |
CAS Number |
1290541-46-6 |
MDL Number |
MFCD03294274 |
Molecular Formula |
C22H17N3O |
Molecular Weight |
339.39 |
Synonyms |
B02 |
Introduction of 1290541-46-6 :
RAD51 Inhibitor B02 (B02) is an inhibitor of human RAD51 with an IC50 of 27.4 μM. IC50 & Target: IC50: 27.4 μM (hRAD51)[1] In Vitro: RAD51 Inhibitor B02 specifically inhibits human RAD51 (IC50=27.4 μM), but not its E. coli homologue RecA (IC50>250 μM)[1]. The combination of B02 with cisplatin has the strongest killing effect on the human breast cancer cells MDA-MB-231[2]. In Vivo: B02 significantly enhances the therapeutic effect of cisplatin on tumor cells in vivo. B02 is tolerated by mice at doses up to 50 mg/kg without obvious body weight loss. No inhibition of tumor growth is observed on mice solely treated by B02. Mice treated with 4 mg/kg cisplatin, however, shows a 33% inhibition of tumor growth. Finally, mice treated with 50 mg/kg B02 and 4 mg/kg cisplatin shows a 66% inhibition of tumor growth[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.