Topiramate D12 (McN 4853 D12) is a deuterium labeled Topiramate. Topiramate is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase^[1][2][3]. IC50 & Target: GluR5 receptor^[1]; GABAergic^[2]; Kainate/AMPA^[2]; Sodium channel^[2]; Calcium channel^[2]; Potassium channel^[2]; Carbonic anhydrase^[2]