Chemical Name |
Zamifenacin (fumarate) |
CAS Number |
127308-98-9 |
MDL Number |
MFCD09263617 |
Molecular Formula |
C31H33NO7 |
Molecular Weight |
531.60 |
Synonyms |
UK-76654 (fumarate) |
Introduction of 127308-98-9 :
Zamifenacin fumarate (UK-76654 fumarate) is a potent gut-selective muscarinic M3 receptor antagonist. Zamifenacin significantly reduces colonic motility in irritable bowel syndrome[1]. IC50 & Target: Muscarinic M3 receptor[1] In Vivo: Zamifenacin exhibits moderate oral bioavailability (mouse 26%, rat 64%, dog 100%) and Cmax (mouse 92, rat 905, dog 416 ng/mL) following oral administration (mouse 13.2, rat 20 and, dog 5 mg/kg)[2].
Zamifenacin exhibits terminal elimination half-lives (mouse 2.1, rat 6.0 and, dog 1.1 h) due to high plasma clearance (68, 35, and 39 mL/min/kg respectively combined with large volumes of distribution (12.5, 19.0, and 3.5 L/kg respectively) following intravenous administration (mouse 5.3, rat 5.0 and, dog 1.0 mg/kg)[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.