| Chemical Name |
MI-3 |
| CAS Number |
1271738-59-0 |
| MDL Number |
MFCD23380587 |
| Molecular Formula |
C18H25N5S2 |
| Molecular Weight |
375.55 |
| Synonyms |
Menin-MLL inhibitor 3 |
Introduction of 1271738-59-0 :
MI-3 (Menin-MLL inhibitor 3) is a potent and high affinity menin-MLL inhibitor with an IC50 of 648 nM and a Kd of 201 nM[1]. IC50 & Target: IC50: 648 nM (menin-MLL); Kd: 201 nM (menin-MLL)[1] In Vitro: MI-3 (12.5-50 μM; HEK293 cells) treatment effectively inhibits the menin-MLL-AF9 interaction in human cells[1].
MI-3 (0-1.6 μM; 72 hours; KOPN-8 and MV4;11 cells) treatment shows an effective and dose-dependent growth inhibition in KOPN-8, MV4 and ME-1 cells[1].
MI-3 (12.5-50 μM; 48 hours; MV4;11 cells) treatment results in a substantial, and dose-dependent increase in Annexin V and AnnexinV/propidium iodide (PI) cells, demonstrating an increase in the number of cells undergoing apoptosis[1].
MI-3 (6.25-25 μM; 6 days; THP-1 cells) treatment results in substantially reduced expression of HOXA9 and MEIS1[1].
| Purity |
NLT 98% |
| Storage |
at 20ºC 2 years |
*The above information is for reference only.
