Chemical Name |
Hydroxyurea |
CAS Number |
127-07-1 |
Molecular Formula |
CH4N2O2 |
Molecular Weight |
76.05 |
Synonyms |
Hydroxycarbamide |
Introduction of 127-07-1 :
Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. In Vitro: Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases[1]. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro[2]. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages[3]. In Vivo: Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice[4].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.