Angiotensin II (3-8), human is a less effective agonist at the angiotensin AT₁ receptor. IC50 & Target: Angiotensin AT₁ receptor^[1] In Vivo: Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances^[1].