Chemical Name |
SR12813 |
CAS Number |
126411-39-0 |
MDL Number |
MFCD00888473 |
Molecular Formula |
C24H42O7P2 |
Molecular Weight |
504.53 |
Synonyms |
GW 485801 |
Introduction of 126411-39-0 :
SR12813 is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM. IC50 & Target: IC50: 0.85 μM (HMG-CoA Reductase) In Vitro: SR-12813 inhibits incorporation of tritiated water into cholesterol with an IC50 of 1.2 μM but has no effect on fatty acid synthesis. Furthermore, SR-12813 reduces cellular 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity with an IC50 of 0.85 μM[1]. Both 25-HC and SR-12813 can kill mammalian cells through blocking the synthesis of cholesterol, thereby they are ideal regents for lethal selection. SR-12813 kills HeLa cells at concentration range from 8 µM to 16 µM. SR-12813 kills wild type cells and mutant cells infected by Ad-Cre (SL-5+Cre), but the mutant SL-5 survives this condition. SR-12813 or 25-HC promotes the degradation of the 95-KDa full-length HMG-CoA reductase in wild type HeLa and SL-5 mutant cells[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.