Siamenoside I is one of the mogrosides that has several kinds of bioactivities. In Vivo: In rat, the metabolic reactions of siamenoside I include deglycosylation, hydroxylation, dehydrogenation, deoxygenation, isomerization, and glycosylation. Siamenoside I and its metabolites are mainly distributed to the intestines, stomach, kidneys, and brain^[1].