TCS 21311
| Chemical Name | TCS 21311 |
|---|---|
| CAS Number | 1260181-14-3 |
| MDL Number | MFCD19380092 |
| Molecular Formula | C27H25F3N4O4 |
| Molecular Weight | 526.51 |
| Synonyms | NIBR3049 |
Introduction of 1260181-14-3 :
TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively[1]. In Vitro: TCS 21311 (NIBR3049) exhibits IC50 values of 1.017, 2.550 and 8.055 μM for JAK1, JAK2 and TYK2, respectively in a enzymatic Jak assay[1].
TCS 21311 (NIBR3049) shows moderate activity in this cellular assay (IC50=689 nM, Jurkat cells), which is in good agreement with its enzymatic Pkc activity[1].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.