Chemical Name |
Prednisolone (disodium phosphate) |
CAS Number |
125-02-0 |
MDL Number |
MFCD00083682 |
Molecular Formula |
C21H27Na2O8P |
Molecular Weight |
484.39 |
Synonyms |
Prednisolone 21-phosphate disodium |
Introduction of 125-02-0 :
Prednisolone disodium phosphate is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Target: Glucocorticoid Receptor Prednisolone irreversibly binds with glucocorticoid receptors (GR) alpha and beta for which they have a high affinity. Prednisolone can activate and influence biochemical behaviour of most cells. The steroid/receptor complexes dimerise and interact with cellular DNA in the nucleus, binding to steroid-response elements and modifying gene transcription. They induce synthesis of some proteins, and inhibit synthesis of others. Prednisolone exerted a delayed biphasic effect on the resistant CCRF-CEM leukemic cell line, necrotic at low doses and apoptotic at higher doses. At low doses, prednisolone exerted a pre-dominant mitogenic effect despite its induction on total cell death, while at higher doses, prednisolone's mitogenic and cell death effects were counterbalanced [1, 2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.