Chemical Name |
Tolterodine |
CAS Number |
124937-51-5 |
MDL Number |
MFCD15147030 |
Molecular Formula |
C22H31NO |
Molecular Weight |
325.49 |
Synonyms |
(R)-(+)-Tolterodine;(+)-Tolterodine;(R)-Tolterodine;PNU-200583 |
Introduction of 124937-51-5 :
Tolterodine(PNU-200583) is a potent muscarinic receptor antagonists that show selectivity for the urinary bladder over salivary glands in vivo. IC50 Value: Target: mAChR in vitro: Carbachol-induced contractions of isolated guinea pig bladder were effectively inhibited by tolterodine (IC50 14 nM) and 5-HM (IC50 5.7 nM). The IC50 values were in the microM range and the antimuscarinic potency of tolterodine was 27, 200 and 370-485 times higher, respectively, than its potency in blocking histamine receptors, alpha-adrenoceptors and calcium channels. The active metabolite, 5-HM, was >900 times less potent at these sites than at bladder muscarinic receptors [1]. in vivo: Tolterodine was extensively metabolized in vivo [2]. In the passive-avoidance test, tolterodine at 1 or 3 mg/kg had no effect on memory; the latency to cross and percentage of animals crossing were comparable to controls. In contrast, scopolamine induced a memory deficit; the latency to cross was decreased, and the number of animals crossing was increased [3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.