Chemical Name |
MG 149 |
CAS Number |
1243583-85-8 |
MDL Number |
MFCD22123243 |
Molecular Formula |
C22H28O3 |
Molecular Weight |
340.46 |
Synonyms |
Tip60 HAT inhibitor |
Introduction of 1243583-85-8 :
MG149 (Tip60 HAT inhibitor) is a selective and potent Tip60 inhibitor with IC50 of 74 uM, similar potentcy for MOF (IC50= 47 uM); little potent for PCAF and p300 (IC50 >200 uM)[1]. IC50 & Target: IC50: 74/47 μM (Tip60/MOF)[1] In Vitro: MG 149 (Tip60 HAT inhibitor), at 200 μM, inhibited about 90% of Tip60 activity but had no inhibitory impact on p300 and PCAF. MG 149 was essentially competitive with Ac-CoA and noncompetitive with the histone substrate. HAT inhibition studies with MG 149 demonstrated that both compounds inhibited the HAT activity of the nuclear extracts of different regions significantly (p < 0.05)[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.