XE 991 dihydrochloride
| Chemical Name | XE 991 dihydrochloride |
|---|---|
| CAS Number | 122955-13-9 |
| MDL Number | MFCD09055426 |
| Molecular Formula | C26H22Cl2N2O |
| Molecular Weight | 449.37 |
Introduction of 122955-13-9 :
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1]. IC50 & Target: IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)[1] In Vitro: XE 991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action[2].
| Purity | NLT 98% |
|---|---|
| Storage | at 20ºC 2 years |
*The above information is for reference only.