Chemical Name |
Stilbamidine |
CAS Number |
122-06-5 |
MDL Number |
MFCD00866610 |
Molecular Formula |
C16H16N4 |
Molecular Weight |
264.33 |
Synonyms |
Ba 2652;Stilbamidin |
Introduction of 122-06-5 :
Stilbamidine is a diamidine compound derived from Stilbene and used chiefly in the form of its crystalline isethionate salt in treating various fungal infections. IC50 & Target: fungal In Vitro: The high-affinity pentamidine transporter (HAPT1) is inhibited by Propamidine but displays only low affinity to Stilbamidine. adenosine-sensitive pentamidine transporter (ASPT1), in contrast, is strongly inhibited by Stilbamidine, and Propamidine. [3H]pentamidine uptake is determined in the presence of various concentrations of adenosine (IC50=1.2 μM) or melarsen oxide (IC50=0.7 μM), as well as in the presence of 250 μM adenosine and increasing concentrations of hypoxanthine, Propamidine (IC50=6.1 μM) and Stilbamidine (IC50=110 μM)[1]. The two diamidine compounds, Stilbamidine and Pentamidine are used to treat in multiple myeloma, a disease in which increase of the globulin content of the serum is of frequent occurrence[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.