| Chemical Name |
(-)-Dizocilpine (maleate) |
| CAS Number |
121917-57-5 |
| MDL Number |
MFCD00082465 |
| Molecular Formula |
C20H19NO4 |
| Molecular Weight |
337.37 |
| Synonyms |
(-)-MK-801 (maleate) |
Introduction of 121917-57-5 :
(-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a Ki of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects[1][2]. IC50 & Target: Ki: 211.7 nM (N-methyl-D-aspartate (NMDA) receptor)[1] In Vitro: (-)-Dizocilpine maleate ((-)-MK-801 maleate) significantly inhibited the uptake of all three (norepinephrine, dopamine and serotonin) monoamine transporters in a dose-dependent manner in HEK cells. The Ki values of (-)-Dizocilpine on the norepinephrine, dopamine and serotonin transporters are 3.7 μM, 40 μM and 47 μM, respectively[2]. In Vivo: (-)-Dizocilpine maleate (0.1 mg/kg; intraperitoneal injection; male adult C57BL/6 mice) treatment induces rapid antidepressant effects in the social defeat stress model[1].
| Purity |
NLT 98% |
| Storage |
at 20ºC 2 years |
*The above information is for reference only.
