Chemical Name |
WZ-3146 |
CAS Number |
1214265-56-1 |
MDL Number |
MFCD18074503 |
Molecular Formula |
C24H25ClN6O2 |
Molecular Weight |
464.95 |
Introduction of 1214265-56-1 :
WZ3146 is a mutant selective EGFR inhibitor with IC50s of 2, 2, 5, 14 and 66 nM for EGFRL858R, EGFRL858R/T790M, EGFRE746_A750, EGFRE746_A750/T790M and EGFR, respectively. IC50 & Target: IC50: 2 nM (EGFRL858R), 2 nM (EGFRL858R/T790M), 5 nM (EGFRE746_A750), 14 nM (EGFRE746_A750/T790M), 66 nM (EGFR) [1] In Vitro: WZ3146 is a novel EGFR inhibitor, suppresses the growth of EGFR T790M containing cell lines and inhibits EGFR phosphorylation[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.