Chemical Name |
INT-777 |
CAS Number |
1199796-29-6 |
MDL Number |
MFCD18837028 |
Molecular Formula |
C27H46O5 |
Molecular Weight |
450.65 |
Synonyms |
S-EMCA |
Introduction of 1199796-29-6 :
INT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM. IC50 & Target: EC50: 0.82 μM (TGR5)[1] In Vitro: INT-777 is a novel potent and selective TGR5 agonist with remarkable in vivo activity[1]. INT-777 (3 μM) increases ATP production in the human enteroendocrine cell line NCI-H716 in a cAMP-dependent manner[2]. INT-777 (10 μM) lowers Isc and increases TEER when added on the serosal side of seromuscular stripped distal colon segments. INT-777 effect on basal secretion is reduced in neuron-free and TTX-treated mucosal-submucosal preparations[3]. In Vivo: INT-777 (1 μM/min/kg, p.o.) has a potent choleretic effect, prevents carboxyl CoA activation and subsequent conjugation, thereby favoring its cholehepatic shunt pathway with a ductular absorption and a potent choleretic effect in HF-fed TGR5-Tg male mice[1]. INT-777 (30 mg/kg/day, p.o.) increases energy expenditure and reduces hepatic steatosis and obesity upon high fat feeding in TGR5-Tg mice[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.