Chemical Name |
NBQX |
CAS Number |
118876-58-7 |
MDL Number |
MFCD00270054 |
Molecular Formula |
C12H8N4O6S |
Molecular Weight |
336.28 |
Synonyms |
FG9202 |
Introduction of 118876-58-7 :
NBQX is a highly selective and competitive AMPA receptor antagonist. IC50 & Target: AMPA receptor[1] In Vitro: NBQX has a high affinity for AMPA and kainate binding sites with little or no affinity for the glutamate recognition site on the NMDA receptor complex[1]. In Vivo: NBQX is neuroprotective in a focal ischaemia model in the rat when given as an i.v. bolus dose of 30 mg/kg at the time of MCA occlusion and again at 1 h post occlusion[1]. NBQX provides potent anticonvulsant protection against AMPA. The ED50 values for the protection against AMPA-induced seizures by NBQX (30 min, i.p.) is 23.6 (11.6- 48.0)[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.