Chemical Name |
Norbinaltorphimine dihydrochloride |
CAS Number |
113158-34-2 |
MDL Number |
MFCD00069374 |
Molecular Formula |
C40H45Cl2N3O6 |
Molecular Weight |
734.71 |
Synonyms |
nor-Binaltorphimine dihydrochloride;nor-BNI dihydrochloride |
Introduction of 113158-34-2 :
Norbinaltorphimine dihydrochloride is a potent and selective κ opioid receptor antagonist. IC50 & Target: κ opioid receptor[1] In Vitro: Norbinaltorphimine reversibly antagonize the effects of κ agonists with pA2 values of 10.2-10.4. Norbinaltorphimine is much less potent as an antagonist at μ and δ receptors, pA2 values are 7.4-7.6 and 7.6-7.8, respectively[1]. In Vivo: Norbinaltorphimine has weak and inconsistent effects on THC-induced taste avoidance in adolescent rats in that Norbinaltorphimine both attenuates and strengthens taste avoidance dependent on dose and trial. Norbinaltorphimine has limited impact on the final one-bottle avoidance and no effects on the two-bottle preference test. Interestingly, Norbinaltorphimine has no effect on THC-induced taste avoidance in adult rats as well[2]. Norbinaltorphimine pretreatment significantly attenuates stress-induced reinstatement of nicotine-CPP, but has no effect on nicotine-primed reinstatement[3].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.