| Chemical Name |
N-(p-amylcinnamoyl) Anthranilic Acid |
| CAS Number |
110683-10-8 |
| Molecular Formula |
C21H23NO3 |
| Molecular Weight |
337.41 |
| Synonyms |
ACA |
Introduction of 110683-10-8 :
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. N-(p-amylcinnamoyl) Anthranilic Acid (ACA) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3]. IC50 & Target: PLA2[1][2].
TRP channel[1][2]. Calcium-activated chloride channels[3]. In Vitro: N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) completely blocks ADPR-induced whole-cell currents and H2O2-induced Ca2+ signals (IC50=1.7 μM) in HEK293cells transfected with human TRPM2[1].
N-(p-amylcinnamoyl) Anthranilic Acid (ACA; 20 μM) also blocks currents through human TRPM8 and TRPC6 expressed in HEK293 cells[1].
N-(p-amylcinnamoyl) Anthranilic Acid (ACA) modulates the activity of different TRP channels independent of PLA22 inhibition[1].
| Purity |
NLT 98% |
| Storage |
at 20ºC 2 years |
*The above information is for reference only.
