Chemical Name |
SNT-207858 |
CAS Number |
1104080-42-3 |
MDL Number |
MFCD20526445 |
Molecular Formula |
C32H45Cl4N5O3 |
Molecular Weight |
689.54 |
Introduction of 1104080-42-3 :
SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor[1]. IC50 & Target: IC50: 22 nM (binding, MC-4 receptor), 11 nM (function, MC-4 receptor)[1] In Vitro: SNT207858 binds to the MC-4 receptor with an affinity of 22 nM and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5[1]. In Vivo: SNT207858 (30 mg/kg; oral administration; once daily; 15 days) significantly reduces the tumor induced weight loss in mice[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.