Chemical Name |
Ch55 |
CAS Number |
110368-33-7 |
MDL Number |
MFCD06798383 |
Molecular Formula |
C24H28O3 |
Molecular Weight |
364.48 |
Introduction of 110368-33-7 :
Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. In Vitro: Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.