β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients. IC50 & Target: Amyloid-β^[1] In Vivo: β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab–Cu²⁺ interaction^[1]. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of K_a10 ⁷ M^-1[2].