Chemical Name |
Jasplakinolide |
CAS Number |
102396-24-7 |
MDL Number |
MFCD00467745 |
Molecular Formula |
C36H45BrN4O6 |
Molecular Weight |
709.67 |
Introduction of 102396-24-7 :
Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a Kd of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, has both fungicidal and anti-cancer activity[1][2]. In Vitro: Jasplakinolide has an IC50 of 35 nM for the antiproliferative effect of jasplakinolide on PC3 prostate carcinoma cells[2].
Jasplakinolide (10 μM; for 2 hours) generates binucleated cells when applied during mitosis. Jasplakinolide induces the formation of F-actin-containing apical extensions in Toxoplasma gondii tachyzoites[2].
Jasplakinolide (1 mM; for 60 min) induces the formation of actin-containing apical extensions in isolated Toxoplasma gondii tachyzoites fixed[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.