Lydimycin is a naturally occurring biotin analogue isolated from Streptomyces lydicus, with antibiotic property. IC50 & Target: Bacterial^[1] In Vitro: Lydimycin (alpha-dehydrobiotin) is a naturally occurring biotin analogue, with antibiotic property. Lydimycin competes with biotin for the fixation on the apocarboxylases, producing irreversibly inactive enzymes^[1]. Lydimycin (alpha-dehydrobiotin) acts as a biotin antimetabolite, and inhibits the synthesis of 7,8-diaminopelargonic acid aminotransferase and the dethiobiotin synthetase enzymes at 1 μg/mL^[2].