Chemical Name |
Microcystin-LR |
CAS Number |
101043-37-2 |
MDL Number |
MFCD00871766 |
Molecular Formula |
C49H74N10O12 |
Molecular Weight |
995.17 |
Synonyms |
Cyanoginosin-LR;MC-LR;Toxin T 17 (Microcystis aeruginosa) |
Introduction of 101043-37-2 :
Microcystin-LR is a potent inhibitor of type 1 and type 2A protein phosphatases (PP1 and PP2A), with IC50s of 1.7 nM and 0.04 nM, respectively. IC50 & Target: IC50: 1.7 nM (PP1), 0.04 nM (PP2A)[1]. In Vitro: Microcystins are toxic molecules produced by cyanobacterial blooms due to water eutrophication[2]. Microcystin-LR proves to be a potent inhibitor of type 1 (IC50=1.7 nM) and type 2A (IC50= 0.04 nM) protein phosphatases. Microcystin-LR inhibits the activity of both type 1 and type 2A phosphatases >10-fold more potently than okadaic acid under the same conditions. Type 2A protein phosphatases in dilute mammalian cell extracts are found to be completely inhibited by 0.5 nM microcystin-LR while type 1 protein phosphatases are only slightly affected at this concentration[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.