Chemical Name |
SIS3 (free base) |
CAS Number |
1009104-85-1 |
Molecular Formula |
C28H27N3O3 |
Molecular Weight |
453.53 |
Introduction of 1009104-85-1 :
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1[1]. IC50 & Target: Smad3, ALK-5[1] In Vitro: SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.