Chemical Name |
ACT 178882 |
CAS Number |
1007392-69-9 |
Molecular Formula |
C33H38Cl3N3O4 |
Molecular Weight |
647.03 |
Introduction of 1007392-69-9 :
ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM. IC50 & Target: IC50: 1.4 nM (Renin)[1] In Vitro: The median time to Cmax (tmax) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t½) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for Cmax and 2.02 (1.75 to 2.34) for AUC∞, indicating a significant interaction between ACT 178882 and diltiazem[2].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.