Chemical Name |
CVT-10216 |
CAS Number |
1005334-57-5 |
Molecular Formula |
C24H19NO7S |
Molecular Weight |
465.48 |
Introduction of 1005334-57-5 :
CVT-10216 is a highly selective, reversible aldehyde dehydrogenase-2 (ALDH-2) inhibitor with an IC50 of 29 nM. CVT-10216 also has inhibitory effect of ALDH-1 with an IC50 of 1.3 μM. CVT-10216 can reduce excessive alcohol drinking in alcohol-preferring rats and exhibit anxiolytic effects[1]. IC50 & Target: IC50: 29 nM (ALDH-2)[1] In Vivo: CVT-10216 (intraperitoneal injection; 3.75, 7.5, or 15 mg/kg) exhibits a increase in social interaction as a dose-dependent manner, punctuated by a 2-fold increase in social interaction after 15 mg/kg in Fawn-Hooded rats[1].
CVT-10216 (intraperitoneal injection; 3.75 or 15 mg/kg) are determined 5 h into the third withdrawal.It has the anxiolytic effect of 15 mg/kg CVT-10216 in this model, but has no significant effects on locomotor activity[1].
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.