Chemical Name |
Ipatasertib-NH2 |
CAS Number |
1001382-14-4 |
Molecular Formula |
C21H26ClN5O2 |
Molecular Weight |
415.92 |
Synonyms |
GDC-0068-NH2;RG7440-NH2 |
Introduction of 1001382-14-4 :
Ipatasertib-NH2 (GDC-0068-NH2;RG7440-NH2) is a ligand for target protein AKT for PROTAC, binds to lenalidomide, a ligand of ubiquitin E3 ligase cereblon (CRBN), via a ten-hydrocarbon linker to form INY-03-041 (HY-133120) to degrade AKT[1]. IC50 & Target: AKT[1] In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
Purity |
NLT 98% |
Storage |
at 20ºC 2 years |
*The above information is for reference only.