Loxoribine
| 화학 이름 | Loxoribine |
|---|---|
| CAS 번호 | 121288-39-9 |
| MDL 번호 | MFCD00867591 |
| 분자식 | C13H17N5O6 |
| 분자 무게 | 339.30 |
| 동의어 | 7-Allyl-8-oxoguanosine; RWJ 21757 |
Introduction of 121288-39-9 :
Loxoribine (7-Allyl-8-oxoguanosine) is a guanosine analog with anti-viral and anti-tumor activities. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist[1][2][3]. IC50 & Target: TLR7[1] In Vitro: Loxoribine induces maturation of human monocyte-derived dendritic cells DCs and stimulates their Th-1- and Th-17-polarizing capability[2].
Loxoribine (250 μM; 48 hours) stimulates maturation of MoDCs as shown by up-regulation of CD80, CD83, CD40, CD54 and CCR7[2].
loxoribine activates cells of the innate immune system selectively via the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1].
In Vivo: Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells in vivo[3].
| 청정 | NLT 98% |
|---|---|
| 저장 | at 20ºC 2 years |
*위의 정보는 참고 용입니다.