Sal003
| 화학 이름 | Sal003 |
|---|---|
| CAS 번호 | 1164470-53-4 |
| MDL 번호 | MFCD00361095 |
| 분자식 | C18H15Cl4N3OS |
| 분자 무게 | 463.21 |
Introduction of 1164470-53-4 :
Sal003 is a potent, specific and cell-permeable inhibitor of the eukaryotic translation initiation factor 2α (eIF2α) phosphatase. Sal003 is a derivative of salubrinal[1]. IC50 & Target: eIF2α phosphatase[1] In Vitro: Sal003 (20 μM; 1-12 hours) sharply increases eIF2α phosphorylation in mouse embryonic fibroblasts (MEFs)[2].
Eukaryotic translation initiation factor 2α (eIF2α) phosphorylation by Sal003 (10 μM; 1 hour) enhances subtilase cytotoxin (SubAB)-induced apoptotic signaling[1].
Sal003 promotes eIF2α phosphorylation leads to impairment of synaptic plasticity and memory[1].
In Vivo: Sal003 (20Μm; intrahippocampal injection; 8 minutes) impairs contextual memory in vivo[1].
| 청정 | NLT 98% |
|---|---|
| 저장 | at 20ºC 2 years |
*위의 정보는 참고 용입니다.