D159687 is a selective PDE4D inhibitor^[1]. IC50 & Target: PDE4D^[1] In Vitro: D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment^[1].
D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM^[1]. In Vivo: D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques^[2].