Doxycycline hydrochloride, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor^[1]. In Vitro: Doxycycline hydrochloride affects growth of glioma cells only under high concentrations^[2].
Doxycycline hydrochloride decreases MT-CO1 protein content with concentrations of 1 µg/mL and higher in SVG cells^[2].
In Vivo: Doxycycline hydrochloride (oral; 200 or 800 mg/kg/day; for 3 months) reduces active MMP-9 in untreated HT mice in a dose-dependent manner^[1]