MCH-1 antagonist 1 is a potent melanin concentrating hormone (MCH-1) antagonist with a K_i of 2.6 nM. MCH-1 antagonist 1 also inhibits CYP3A4 with an IC₅₀ of 10 μM. IC50 & Target: Ki: 2.6 nM (MCH-1)^[1]
IC50: 10 μM (CYP3A4)^[1] In Vitro: MCH-1 antagonist 1 (Compound 1) also inhibits cytochrome P450 3A4 (CYP3A4) with an IC₅₀ of 10 μM^[1]. In Vivo: MCH-1 antagonist 1 is administered to male C57BL/6J DIO mice to assess their pharmacokinetic profile. Effect of MCH-1 antagonist 1 (dosed at 30 mg/kg, po) is measured on the body weight of DIO mice with the AUC_{0-6 h} of 14760 h*ng/mL^[1].